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Hypertension and metabolic syndrome together lead to more cases of left ventricular hypertrophy, microalbuminuria, increased intima-media thickness, and hypertensive retinopathy (115)

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Previous in vivo human data have shown that the plasma concentrations of APR-246 in the 12 h following its intravenous administration range from 50 to 500 mM, suggesting that concentrations above 50 mM are suitable for in vitro studies of the early effects of APR-246

Yang D, Zhu J, Zhou X, Pan D, Nan S, Yin R, et al

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