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doi: 10.1016/j.intimp.2025.114192

Figure 2 In summary, Metabolomics studies have consistently demonstrated that the intestinal metabolite profiles of IBD patients differ significantly from those of healthy controls, including alterations in short-chain fatty acids (SCFAs), bile acids, and tryptophan-derived metabolites, which are repeatedly observed across independent cohorts (177, 178)

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In vivo experimental data demonstrated that PA eye drops contributed to the restoration of corneal structure and function, while hydrogel formulations of PA enabled more sustained drug release and thereby yielded further improved therapeutic efficacy (165)