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GSSG is potentially toxic to cells, but high glutathione reductase activity allows most of the GSH to be maintained in reduced form

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Getting into the body faster isn't the same question as staying biologically active once there

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Indeed, it was demonstrated that heterodimerization of 1-cysPrx with GSH-saturated GSTP results in S -glutathionylation of the oxidized cysteine in 1-cysPrx followed by subsequent spontaneous reduction of the mixed disulfide and restoration of enzymatic activity (Manevich et al., 2004)