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Gastrodin inhibits HO-induced ferroptosis through the antioxidative effect in rat glioma cell line C6 ( Some studies have shown that valproic acid (VPA) treatment contributes to iron metabolism in epilepsy, leading to the formation of non-transferrin-bound iron (NTBI) and an increase in oxidative stress

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However, effects on advanced fibrosis remain under investigation, with phase 2 trials of semaglutide showing MASH resolution without confirmed fibrosis improvement

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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines, but no NNMT inhibitor has reached regulatory approval to date