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cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act synergistically to generate downstream signals resulting in increased insulin secretion (8)

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Again, if we go back to the data and look at another population-based cohort study, the risk for major depressive disorder was higher among patients with acne than in the general population without acne and the risk was unchanged after excluding patients who received isotretinoin

Fifth, the data may not encompass all potential confounding factors that could influence the outcome of interest