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Bastin J, Lopes-Costa A, Djouadi F

Serious side effects include pancreatitis (severe abdominal pain), gallbladder disease, acute kidney injury, thyroid tumors (boxed warning), and diabetic retinopathy complications

Some people wonder whether the B12 in their compounded semaglutide is sufficient to prevent deficiency or if they need additional supplementation

And Wegovy (injection) is FDA-approved for adults and kids older than 12 years old with obesity or who have weight-related health issues like high cholesterol, type 2 diabetes, or high blood pressure, says Dr

The American College of Rheumatologys 2025 annual conference (ACR Convergence 2025) added to this picture, with data suggesting that patients on GLP-1 drugs had fewer rheumatic disease flares and that those with osteoarthritis saw greater improvements in pain and function compared to those on SGLT2 inhibitors, another diabetes drug class [11]