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Model assumptions will need continual refining as new evidence emerges and as new indications for incretin and hormone-based medications are approved

The answer is: it has shown anti-aging effects in animal models, but not yet in humans

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Proinflammatory mediators such as interleukin-6 (IL-6), interleukin-1 (IL-1), and LPS have also been reported to directly stimulate GLP-1 secretion from intestinal endocrine L cells

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