Semaglutide tends to be the better fit when: the goal is a 10 to 15 percent weight reduction, the patient has documented cardiovascular disease or is at high cardiovascular risk and wants the medication with the most outcomes data, cost or access constraints favor it, or the patient has tolerated single-pathway GLP-1s well in the past
Weeks 1-4: 2mg Retatrutide weekly, subcutaneous injection
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