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These include: Nausea and vomiting Diarrhoea Reduced appetite and fluid intake These effects can lead to inadequate hydration and depletion of essential electrolytes such as sodium, potassium, magnesium, and calciumall of which are crucial for normal muscle function

Risk ratios (RR) for nonfatal myocardial infarction estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons

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Sanofi, having experienced a mid-stage trial failure with a previous GLP-1 drug, is exploring potential next-generation treatments that could offer fewer side effects