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Gastrointestinal adverse events in all treatment groups were more common among women than men, but rates of premature treatment discontinuation were similar for both genders

A study in C57BL/6J mice using a dose comparable to a 5000 g tablet (30.46 g/day) for humans found a depletion in Bacteroides but no change in cecal short-chain fatty acids (SCFAs) or markers of dextran sulfate sodium (DSS)-induced colitis with B12 treatment, including colon length and fluorescein isothiocyanate-dextran permeability test [15]

[DOI] [PubMed] [Google Scholar] 85.Giugliano D., Scappaticcio L., Longo M., Caruso P., Maiorino M.I., Bellastella G., Ceriello A., Chiodini P., Esposito K

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All three approved sitesabdomen, thigh, and upper armdeliver equivalent medication exposure