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Moreover, early experiments in rat kidney tubules using transmission EM showed that the flux of large molecules across the paracellular route is selectively regulated by complex tight junction strands (7, 9)

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Days 7-14: Initial improvements in pain levels, reduced swelling, and early signs of healing become more consistently reported

Fibroblasts multiply, laying down extracellular matrix (ECM) components like collagen III (temporary, flexible stuff)