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In the H 2 O 2 -independent pathway, GPX3 modulates epigenetic responses by repressing S-glutathionylation of a signal transducer linked to histone modification (Jasmine and Joyous, 2022)

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Beyond this remodeling effect, berberine hydrochloride down-regulates the efflux-pump gene CDR1 , reducing fluconazole extrusion and further sensitizing resistant strains (Zhu et al., 2014)

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