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Only studies evaluating the effectiveness of oral vitamin B12 replacement on pernicious anemia patients in entirety or as a subset were included for review
At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story
That includes signals tied to swelling, oxidative stress, and tissue breakdown
Consequently, the excess acidity may harm the inner lining of the stomach
Additional diagnostic tests like an upper endoscopy or bowel biopsy may also be required
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