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Additional genetic polymorphisms occurring in choline and one-carbon metabolic pathways may alter the dietary requirement for choline and thus increase the likelihood of developing signs of deficiency when choline intake is inadequate (9, 20, 21)

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Spinal cord injury For many decades, since the 1940s, based purely on correlative observations, reactive astrocytes that surround tissue lesions after traumatic injuries or stroke were regarded as glial scars that were the primary cause for the failure of axon regeneration and functional recovery after spinal cord injury (SCI) and other causes of axotomy in the CNS

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