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Recent studies show that metformin can alleviate age-associated inflammation by increasing autophagy and improving mitochondrial function, both of which are relevant biological features involved in PD-related cellular damage pattern (Jung et al., 2012), a mechanism that can protect pancreatic cell against lipotoxicity

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When the gut is inflamed and filled with partially digested, fermenting proteins, the vagus nerve transmits distress signals directly to the brain