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These stress response modulation properties have significant implications for developing peptide-based treatments for stress-related disorders, burnout syndrome, and understanding the bidirectional relationship between stress and sleep quality

Highlights GLP-1 medicines reduce fat and liver mass more rapidly than skeletal muscle (SKM) Running performance is maintained or improved in mice on GLP-1 medicine GLP-1 medicine modifies the SKM proteome despite similar weight loss as calorie restriction Patients on GLP-1 medicine slightly reduce SKM mass but largely maintain strength Summary The large decrease in body weight with glucagon-like peptide-1 (GLP-1) medicines raises concern about a loss of lean body mass (LBM) and skeletal muscle

Weight Gain: In rare cases, a high dose of glutathione injections can also lead to weight gain

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and abroad: Though some patients have described severe psychological reactions to GLP-1 receptor agonists, doctors arent noticing a trend and clinical trials dont suggest that these side effects are correlated with the drugs