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Precautions should be taken in patients with kidney disease, low potassium levels, or history of allergy to Vitamin B12

Complicating the pharmacology, certain antiarrhythmic drugs (AADs) exhibit a wide range of electrophysiological and pharmacological actions that can vary with method of administration, plasma concentration, and the presence of active metabolites (4)(5)

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The same dose is recommended in the USA and in Australia, except that in the USA, the oral dose has been reduced to 350 mg per dosage unit in prescribed preparations [87, 88]