Knockdown of LONP1 in alveolar type 2 (AT2) cells induces the expression of senescence-associated secretory phenotype factors [i.e., plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor- (TGF-)], as well as senescence markers (such as p53 and p21), and leads to G2 phase cell cycle arrest [71]
An endotoxin-free peptide helps ensure that observed experimental outcomes are attributable to the peptide itself rather than unintended immune or inflammatory responses caused by endotoxin contamination
2016 Sep 1;311(3):C386-91
Harvey C, Thimmulappa R, Singh A, Blake D, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S
If you are in eating disorder recovery or treatment and are considering GLP-1 medications, or if you are currently taking GLP-1s and have concerns about eating disorder symptoms, please consult with your treatment team, including your physician