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The first step of LOXs catalysis is to abstract an unstable hydrogen from the bis -allyl position at a PUFA to form a pentadienyl radical (L) ( 2 ) can take a hydrogen atom from the bis -allyl position of a PUFA (Yin et al., 2011)

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Several new therapeutic agents are currently under investigation for AIH, including B-cell activating factor (BAFF) inhibitors, low-dose IL-2, Toll-like receptor-4 antagonists, pre-implantation factor, and inflammasome inhibitors among others [132]

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Accessed January 14, 2025