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Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]

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Monitor Performance Signals, Not Just Body Weight If body weight is decreasing while power, pace, recovery, or training tolerance are also declining, this is a clear signal of insufficient fueling

However, this could change with several key policy shifts on the horizon