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Compared with differentiated tumor cells, CSCs rely heavily on lipid metabolism to maintain their stemness and fulfill intracellular biosynthesis and energy metabolism requirements (89)

Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (36, 83)

Acknowledgments We thank the patient for permitting us to use his data to complete this article

Funding: This work was supported by the Department of Science and Technology, India, Grant no

Understanding the Enemy: The Immunology of RA To conquer RA, we must first map its treacherous terrain