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Here are some cases: A 52-year-old woman reacted to an intramuscular cyanocobalamin B12 shot, but later received oral B12 with no adverse effects

The compound was never approved as a pharmaceutical treatment for obesity because the Phase 2 clinical trial results, while showing safety and modest efficacy, did not meet the threshold for drug registration

Enhance post-competition recovery by restoring a healthy metabolic rate after prolonged dieting

"Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies"