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Due to CR-induced immune system depletion and mutagenesis/genotoxic events (leading to occurrence and accumulation of a driver mutation and genome instability), the risks of oncogene activation and tumor suppressor depletion required for conversion to tumorinitiating cells over long periods could increase (60)

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The strongest responses tend to come from people who are consistent with weekly dosing, follow through on lifestyle changes alongside medication, and work with a provider to adjust dosing at the right pace

doi:10.3390/ijms20040867 [PubMed] [MDPI] [PubMed] Viroonudompho D, Kanjanachumpol S, Sirisate S

According to Reuters, the EMA advised that patients who experience sudden vision loss or worsening eyesight should stop treatment immediately and seek medical advice