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Our results suggest that CBS of the TSS pathway plays an important role in maintaining cysteine levels under restricted cystine availability or excess hemin exposure, and CBS upregulation by DMF increases the cellular glutathione levels to protect against ROS and ferroptosis stress in SCD

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Lilly also originated mazdutide (out-licensed to Innovent for China) and is collaborating with Chugai on orforglipron in Japan