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The data suggests retatrutide's triple-agonist mechanism already delivers substantially greater effects than semaglutide alone further supporting the argument that adding semaglutide to retatrutide is pharmacologically redundant

For instance, identification of suicidal outcomes by means of ICD codes registered during routine clinical practice databases has been associated with a slight under-registration of cases, which may result in underestimation of the association between drug exposure and SIS outcomes [35], and studies validating suicidal classification have concluded that ICD codes have good positive predictive value but low specificity [36]

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