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In a clinical setting, the loss of lean mass associated with some IF protocols, could exacerbate sarcopenia in older adults or individuals with chronic conditions and compromise cardiovascular resilience

By measuring the -oxidation of [1- 14 C] palmitate in the mitochondria or peroxisome of the liver or muscle, the present study first indicated that dietary L-carnitine supplementation mainly increased mitochondrial FA -oxidation activity, but not peroxisomal activity, at least in zebrafish

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Age-dependent decrease of carnitine content in muscle of mice and humans

have shown that ALC supplementation (0.3, 0.6 and 1.2 mM for 5 h and 24 h) in mouse fibroblast culture media stabilizes the mitochondrial membrane, increases energy supply to the organelle and protects the developing cell from apoptosis through the mitochondrial pathway [57]