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Vegans tend to have significantly lower baseline L-carnitine levels because the richest dietary sources are animal products such as red meat, dairy, and fish

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

1994 Nov;43(3):351-9. [PMID: 7966443]

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Future research should aim to elucidate the mechanisms underlying semaglutides impact on the digestive system, explore the dose-response relationship concerning acid reflux, and assess long-term outcomes in diverse patient populations