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Abbreviations ADA Adenosine deaminase ADVANCE Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation Afib Atrial fibrillation BNP Brain natriuretic peptide cAMP Cyclic adenosine 3,5-monophosphate CI Confidence interval CKD Chronic kidney disease CVD Cardiovascular disease CVOTs Cardiovascular outcome trials DPP-4 Dipeptidyl peptidase-4 DPP-4i DPP-4 inhibitor eGFR Estimated glomerular filtration rate FDA Food and Drug Administration GAS Interferon-gamma-activated sequence GIP Glucose-dependent insulinotropic polypeptide GLP-1 Glucagon-like peptide-1 GLP-1R GLP-1 receptor GLP-1RAs Glucagon-like peptide-1 receptor agonists HbA1c Glycated hemoglobin HDL High-density lipoprotein HF Heart failure HNF-1 Hepatocyte nuclear factor-1 HR Hazard ratio hs-CRP High-sensitivity C-reactive protein IL-12 Interleukin-12 IVUS Intravascular ultrasound LDL Low-density lipoprotein LVEF Left ventricular ejection fraction MACE Major adverse cardiovascular events MI Myocardial infarction MMPs Matrix metalloproteases PAI-1 Plasminogen activator inhibitor-1 PCI Percutaneous coronary intervention PKA Protein kinase A PWV Pulse wave velocity SGLT-2i Sodium/glucose cotransporter-2 inhibitors STAT1 Signal transducer and activator of transcription 1 T1DM Type 1 diabetes mellitus T2DM Type 2 diabetes mellitus TGF- Transforming growth factor- TLR4 Toll-like receptor 4 TNF- Tumor necrosis factor- TRIF TIR-domain-containing adapter-inducing interferon- UKPDS United Kingdom Prospective Diabetes Study VLDL Very low-density lipoprotein Author contributions MR performed literature search

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