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In addition, the available evidence suggests an effect in reducing the incidence and severity of AMS in humans ( 2 Methodology 2.1 Study design The research design followed the PRISMA 2020 protocol for systematic reviews and meta-analyses, aiming to identify studies evaluating the effect of antioxidant therapies on Acute Mountain Sickness, a condition resulting from high-altitude exposure (Figure 1)

Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines