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2 (download XLSX Source data for Extended Data Fig

Lv Q, Wang L, Luo X, Chen X

Contraindications Orlistat is contraindicated in patients with: Chronic malabsorption syndrome Cholestasis (blocked bile flow from the liver) Known hypersensitivity to orlistat or any component of the formulation Pregnancy and breastfeeding Monitoring and Duration of Use Treatment with orlistat should be discontinued after 12 weeks if a patient has not lost at least 5% of their initial body weight

Serum stability An appropriate amount of ORI@CPD-Lipo solution was mixed with fetal bovine serum in a 96-well plate, and the absorbance at 490 nm was measured using a microplate reader (MULTISKAN Sky 1530, Thermo Fisher, USA) at 0, 1, 4, 8, 12, and 24 h