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Comorbidities were identified by relevant codes in at least two outpatient records within 2 years, one inpatient record or the problem list before T0

Cartilage nodule formation assay in micromass culture Briefly, chondrocytes were seeded in a 12-well plate at a density of 1.010 5 cells per well in a final volume of 10 L and incubated for 2 h at 37 C to allow adherence