[4] Primary constipation (functional constipation) [5] [6] [7] Constipation with no identifiable secondary cause Subtypes Normal transit constipation (most common): symptoms of constipation despite normal colonic transit time Defecatory disorders (also known as outlet obstruction or pelvic floor dyssynergia): difficulty evacuating stool once it reaches the rectum Can manifest with prolonged straining, rectal discomfort, and trouble passing even soft stools May be caused by inadequate rectal propulsion, increased resistance to evacuation , or other factors Slow-transit constipation Risk factors for primary constipation [6] Lifestyle: poor diet, insufficient physical activity, obesity Genetic predisposition Psychological and behavioral disorders Alterations in normal gut flora, colonic dysmotility [5] A predominance of abdominal bloating, cramping, and pain associated with constipation should increase the suspicion for IBS-C
MT-2, on the other hand, affects a broader range of receptors, producing quicker and more intense tanning, while also having effects on appetite, metabolism, and sexual function
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