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In a 2024 cryo-EM structure paper published in Cell Discovery, researchers resolved retatrutide bound to each of the three receptors and showed the same peptide adopting a continuous alpha-helical conformation across all three, with receptor-specific contacts in the extracellular loops that tune potency at each target

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Diabetics are more likely to experience cataracts since high blood sugar levels promote binding of sugars (glycation) to proteins in the eye lens (Stevens 1995