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While some studies have shown a correlation between computational results on mTYR and experimental results on human tyrosinase (hTYR) 8 , the lack of a resolved hTYR crystal structure has hindered a deeper understanding of the inhibitory mechanisms of many compounds against hTYR

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In a manner analogous to other tissues, this family of proteins can act as agonists for IGF-I or can block the actions of IGF-I by preventing access to the IGF1R in bone

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