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Respiratory infections: Glutathione plays a protective role in the lung epithelium, which is exposed to high levels of oxidative stress from inhaled pollutants and pathogens
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According to the notion that increased erythropoiesis increases the risk of folic acid shortage, folic acid is frequently advised for SCD patients [98]
Moreover, the interaction between hyperglycemia-driven immune impairment and hypoxic niches highlights a vicious cycle for pathogen recalcitrance, yet prevalent therapies fail to account for this multifactorial etiology, requiring integrated strategies that target both microbial and host determinants for durable outcomes
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