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Mean change in body weight from baseline: Cl=confidence interval

Mioduchoski, FNP-BC Karla K

Additionally, metabolic adaptations that occur during weight lossincluding reduced energy expenditure and hormonal changes that promote weight regainare no longer counteracted by the medication's effects

A minimum cycle length of 3 months per medication is a reasonable floor, and 6 months per cycle allows for full dose titration and a meaningful period at therapeutic doses