Thiamine hydrochloride (vitamin B1) in the formulation is known to cause life threatening anaphylaxis especially on multiple administrations if patient is allergic to it
Somatostatin the inhibitory signal that suppresses GH release
This is all about increasing blood flow to the GI tract, and increasing parasympathetic tone in the enteric nervous system (ENS)
These numbers suggest that some of the headaches could be related to other things rather than the medication, but many real-world users continue to report new or worsening headaches after starting semaglutide, so it is worth considering that the two may be related

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