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To treat rheumatoid arthritis, multifunctional nanoparticles of hydrochloride SIN (HA@M@PB@SINNPs) was designed, using hyalu-ronic acid (HA) as a targeting molecule, with the drug loaded onto PBNPs to form PB@SINNPs The red blood cell membrane and macrophage membrane were fused by sonication and subsequent magnetic stirring at 37 C to form hybrid vesicles, which were then used to disguise PB@SINNPs (151)

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doi: 10.1056/NEJM197703172961115 61 SullivanP