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The most comprehensive review to date, published in JAAOS Global Research & Reviews , reached the same conclusion: Although preclinical studies are promising, there is a current lack of clinical trials (Rahman et al., 2026)
PMC Article PMC4508379
Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with obesity without type 2 diabetes mellitus: a randomized dose-ranging study
WADA applies a three-part assessment to determine if a substance or method is included on the Prohibited List
This approach uses higher daily doses during the first 4 weeks before tapering to maintenance
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