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The binding of growth hormone possibly triggers the activation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway

Myokines produced by skeletal muscle, such as interleukin-6 (IL-6) and irisin, play a key role in mediating these immune and metabolic responses through autocrine, paracrine, and endocrine effects

However, it will still take quite a while before all the most potential innovations get from the bench to the bedside, not the least due to the various limitations and challenges when translating preclinical research findings into the clinic [229, 247, 248]

However, fasting also predictably induces compensatory physiologic responses, such as increased appetite signaling and reduced energy expenditure, which may undermine long-term durability

For patients who want prescription-level weight loss, GLP-1 weight loss treatment may be a better fit