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Type 1 vs Type 2 Diabetes: A Fundamental Difference Type 2 Diabetes Insulin is still produced (at least initially) There is insulin resistance GLP-1 agonists stimulate insulin secretion (in a glucose-dependent way) Type 1 Diabetes The pancreas produces little to no insulin Insulin must be given externally There is no reserve safety net In Type 1 diabetes, insulin is not just for glucose control it is a critical anti-ketogenic hormone