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Second, the current gold standard procedure for cell mobilization is with granulocyte-colony stimulating factor (G-CSF) but this is contraindicated in patients with SCD due to risk of causing complications such as pain crisis, acute chest syndrome, and even death, from the increased white cell counts

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Thus, while ATRA isnt a direct antioxidant, its gene regulatory actions are vital in mitigating oxidative stress and supporting melanocyte function within the skin