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While the LoF of the Methyl-CpG-binding Protein 2 ( MECP2 ) gene is causative to RTT, a duplication of the MECP2 results in MECP2 Duplication Syndrome (MDS) [10, 42]
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In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation
Oxidative stress is one of the important mechanisms for cell damage and disease occurrence
Nagy, C
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