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With this biotransformation, liver detoxification, a long-standing barrier in nanomedicine translation, can be turned into a bridge toward maximizing targeting and minimizing nanotoxicity

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The improved insulin sensitivity after GLP-1MK-801 treatment was confirmed in a 2-week study that, in addition to the pharmacological groups, included a calorie-restricted group weight-matched to the GLP-1MK-801 group (Extended Data Fig