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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

Age-related anabolic resistance diminishes the muscle-preserving effects of protein intake and exercise during weight loss [36]

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Peptide and injection therapies are generally self-pay services and are not covered by standard health insurance plans

Age-related comorbidities (metabolic syndromes) such as, obesity, T2DM, asthma, and CVD, could also increase severity and mortality in elderly COVID-19 patients