In the Chub-S7 cells and primary Sc adipocytes from all metabolic phenotypes including lean, overweight, obese, and morbid obese, we found a significant reduction in the expression of FAO genes including MCD, CPT1, ACADL, CPT2, ECHS1, and ACAA2 in low B12 (Fig
Fish and shellfish: Fish such as salmon, trout, and haddock, as well as shellfish such as clams and mussels, are all rich in vitamin B12
It could also result from other genetic mutations, such as in the cystathionine-beta-synthase (CBS) gene
Long-term safety, carcinogenicity risk, and drug interactions in humans are unknown
While the peptide does not increase IGF-1, caution is warranted given the theoretical relationship between growth factors and cancer progression