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10.1016/j.bbrc.2011.06.013 97 ParkH

Consent for publication No individual-level data were involved, and no consent for publication is needed for this study

DSIP (Delta Sleep-Inducing Peptide) Best for: Sleep disruption and nighttime recovery Mechanism: DSIP is a naturally occurring nonapeptide that promotes slow-wave (delta) sleep by interacting with GABAergic and glutamatergic (NMDA) neurochemical systems, reducing cortisol and ACTH output without forcing sedation

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Again, this factor is limited by patient insight (the hardest thing to get across in treating melasma)