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121, e2321972121

10.1016/j.biopha.2021.112115 52 YangF.TongJ.LiH.ChenJ.DaiL

In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)