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Effects of Liraglutide Compared With Placebo on Events of Acute Gallbladder or Biliary Disease in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events in the LEADER Randomized Trial

57 Furthermore, a subsequent prespecified analysis of the trial examined the effects of semaglutide in patients with and without history of HF at enrolment, with a significant reduction in MACE in patients with HFrEF and HFpEF and a 21% and 25% reduction in the HF composite endpoint, respectively

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The base case that was assumed for the semaglutide pill continuation rate was the continuation rate for sitagliptin