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MODY6: Results from mutations in the gene (NEUROD1) encoding the bHLH transcription factor NeuroD1

These include certain antipsychotics (olanzapine, quetiapine, risperidone), mood stabilizers (lithium, valproate), some antidepressants (mirtazapine, paroxetine, amitriptyline), corticosteroids (prednisone), certain diabetes medications (insulin, sulfonylureas, thiazolidinediones), some beta-blockers (propranolol, metoprolol), and anticonvulsants (gabapentin, pregabalin)

The algorithm allows full flexibility of the ligand and partial flexibility of the protein

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doi: 10.1016/j.bbrc.2014.10.029 58 BahadoranZMirmiranPKashfiKGhasemiA